Concerning the article by Louveau et al “Clinical value of early detection of circulating tumour DNA BRAFV600mut in patients with metastatic melanoma treated with a BRAF inhibitor”
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Clinical value of early detection of circulating tumour DNA-BRAFV600mut in patients with metastatic melanoma treated with a BRAF inhibitor
BRAFV600 mutations (BRAF) are detected in about 50% of lesions from patients with metastatic melanoma. In the last few years, clinical treatment of melanoma has benefited from the approval of personalised therapies targeting BRAFV600. These innovative therapies still require molecular biomarkers predicting response duration. Circulating tumour DNA (ctDNA) appears to be a promising tool thanks t...
متن کاملUsefulness of immunocytochemistry for the detection of the BRAF(V600E) mutation in circulating tumor cells from metastatic melanoma patients.
TO THE EDITOR Metastatic melanoma patients harboring a BRAF gene mutation on codon 600 can be treated with targeted therapies (Flaherty, 2012). Depending on the content of tumor cells and on the analytical sensitivity, BRAF mutations are found in 50–70% of metastatic melanoma patients (Davies et al., 2002). Around 80% display a valineto-glutamic acid substitution (V600E) and B16% harbor a valin...
متن کاملDabrafenib in an elderly patient with metastatic melanoma and BRAF V600R mutation: a case report
BACKGROUND Approximately 50 % of malignant melanomas harbor activating point mutations in the BRAF gene. Typically, these mutations result in the substitution of the amino acid valine at codon 600 of the gene, and 90-95 % of mutations are either BRAF (V600E) or BRAF (V600K). Specific BRAF inhibitors such as dabrafenib and vemurafenib are the mainstays of treatment in patients with metastatic BR...
متن کاملMelanoma Genetics/Genomics
Gene mutations represent a major driving force in the onset and progression of melanoma. Consequently many genes are being investigated for their role in melanomagenesis, including not only inherited genes but also genetic defects that are acquired due to environmental factors, such as excessive sun exposure. The field of melanoma genetics thus encompasses genes in familial melanoma through to ...
متن کاملImmunohistochemical Investigation of Mutant BRAF V600E in Common Pigmented Skin Neoplasms, Study on a Sample of Iranian Patients
Background & Objective: This study was designed for the first time for the detection of mutant BRAF V600E and its correlation with clinicophathologic features in a sample of Iranian patients with pathologically proved pigmented skin neoplasms.Methods: 82 paraffin-embedded blocks, including melanocytic nevi, malignant melanoma, Basel cell carcinoma, and sq...
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